Lentiviral vectors encoding short hairpin RNAs efficiently transduce and knockdown LINGO-1 but induce an interferon response and cytotoxicity in central nervous system neurones

Hutson, Thomas H, Foster, Edmund, Dawes, John M, Hindges, Robert, Yáñez (or Yáñez-Muñoz) , Rafael J. and Moon, Lawrence D F

(2012)

Hutson, Thomas H, Foster, Edmund, Dawes, John M, Hindges, Robert, Yáñez (or Yáñez-Muñoz) , Rafael J. and Moon, Lawrence D F (2012) Lentiviral vectors encoding short hairpin RNAs efficiently transduce and knockdown LINGO-1 but induce an interferon response and cytotoxicity in central nervous system neurones. Journal of Gene Medicine, 14 (5).

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Abstract

Knocking down neuronal LINGO-1 using short hairpin RNAs (shRNAs) might enhance axon regeneration in the central nervous system (CNS). Integration-deficient lentiviral vectors have great potential as a therapeutic delivery system for CNS injuries. However, recent studies have revealed that shRNAs can induce an interferon response resulting in off-target effects and cytotoxicity.

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This is a Submitted version
This version's date is: 2012
This item is not peer reviewed

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https://repository.royalholloway.ac.uk/items/b0efb702-397e-6744-648d-2b9a5077d901/1/

Item TypeJournal Article
TitleLentiviral vectors encoding short hairpin RNAs efficiently transduce and knockdown LINGO-1 but induce an interferon response and cytotoxicity in central nervous system neurones
AuthorsHutson, Thomas H
Foster, Edmund
Dawes, John M
Hindges, Robert
Yáñez (or Yáñez-Muñoz) , Rafael J.
Moon, Lawrence D F
DepartmentsFaculty of Science\Biological Science

Identifiers
doihttp://dx.doi.org/10.1002/jgm.2626

Deposited by Research Information System (atira) on 05-Jun-2012 in Royal Holloway Research Online.Last modified on 05-Jun-2012

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Copyright © 2012 John Wiley & Sons, Ltd.

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