Improving treatment satisfaction and other patient-reported outcomes in people with type 2 diabetes: the role of once-daily insulin glargine

Clare Bradley and Charles J.B Gillbride


Clare Bradley and Charles J.B Gillbride (2008) Improving treatment satisfaction and other patient-reported outcomes in people with type 2 diabetes: the role of once-daily insulin glargine. Diabetes, Obesity and Metabolism, 10 (supplement 2).

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Insulin therapy becomes essential for many people with Type 2 diabetes. After starting insulin, people with diabetes that is poorly controlled with oral agents typically report improved well-being and treatment satisfaction. However, healthcare professionals and people with Type 2 diabetes are often reluctant to begin insulin treatment, citing such concerns as time/resources needed to educate patients, increased risks of hypoglycaemia and fear of injections, which lead them to focus on intensifying conventional oral therapy. Insulin glargine, which offers people with diabetes a once-a-day injection regimen with low risk of hypoglycaemia, is more likely to overcome such initial barriers than other more complex insulin regimens. Once-daily insulin glargine, in combination with modern glucose-dependent oral agents that do not need to be chased with food to prevent hypoglycaemia, does not require the fixed meal times and set amounts of carbohydrates necessary with twice-daily injection mixes and older sulphonylureas. We know it is such dietary restrictions that cause the most damage to quality of life (QoL). To avoid damaging QoL unnecessarily and to ensure optimal satisfaction with treatment it is important to evaluate the effects of treatment on QoL, treatment satisfaction and other patient-reported outcomes using questionnaires validated for this purpose, such as the widely used Diabetes Treatment Satisfaction Questionnaire and the Audit of Diabetes-Dependent Quality of Life measure. A systematic electronic literature search identified reports of studies evaluating patient-reported outcomes associated with insulin glargine in comparison with other treatments. The studies demonstrate that insulin glargine is usually associated with greater improvements in treatment satisfaction and other patient-reported outcomes compared with intensifying oral therapy or alternative insulin regimens.

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Item TypeJournal Article
TitleImproving treatment satisfaction and other patient-reported outcomes in people with type 2 diabetes: the role of once-daily insulin glargine
AuthorsBradley, Clare
Gilbride, Charles J.B.
Uncontrolled KeywordsAudit of Diabetes-Dependent Quality of Life; Diabetes Symptom Checklist; Diabetes Treatment Satisfaction Questionnaire; EQ-5D; health status; insulin glargine; patient-reported outcomes; SF-36; treatment satisfaction; Well-Being Questionnaire;
DepartmentsFaculty of Science\Psychology



Deposited by () on 23-Dec-2009 in Royal Holloway Research Online.Last modified on 12-May-2010


The definitive version is available from Wiley Interscience at the official .url. The authors' final draft here is made available for the purposes of private study or research, and may not be redistributed.


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