Keers, Robert, Pedroso, Inti, Breen, Gerome, Aitchison, Kathy J, Nolan, Patrick M, Cichon, Sven, Nöthen, Markus M, Rietschel, Marcella, Schalkwyk, Leonard C and Fernandes, Cathy (2012) Reduced anxiety and depression-like behaviours in the circadian period mutant mouse afterhours. PLoS One, 7 (6).
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Disruption of the circadian rhythm is a key feature of bipolar disorder. Variation in genes encoding components of the molecular circadian clock has been associated with increased risk of the disorder in clinical populations. Similarly in animal models, disruption of the circadian clock can result in altered mood and anxiety which resemble features of human mania; including hyperactivity, reduced anxiety and reduced depression-like behaviour. One such mutant, after hours (Afh), an ENU-derived mutant with a mutation in a recently identified circadian clock gene Fbxl3, results in a disturbed (long) circadian rhythm of approximately 27 hours.
This is a Submitted version This version's date is: 2012 This item is not peer reviewed
https://repository.royalholloway.ac.uk/items/71cd9a82-b3ab-7802-7a08-3c359f52ea13/4/
Deposited by Research Information System (atira) on 03-Jul-2014 in Royal Holloway Research Online.Last modified on 03-Jul-2014